RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
Parp1
RNA ID
RNA Type
mRNA
Alteration Pattern
dna methylation
Species
mus musculus
Detection Methods
qPCR; PARP assay etc.
Target
NA
Pathway
NA
PubMed ID
Title
Regulation of myofibroblast differentiation by poly(ADP-ribose) polymerase 1
Year
2013
Function
"Poly(ADP-ribosyl)ation (PARylation) is a post-translational protein modification effected by enzymes belonging to the poly(ADP-ribose) polymerase (PARP) superfamily, mainly by PARP-1. Overexpression of PARP-1activated expression of the a-SMA gene (Acta2) in lung fibroblasts. Suppression of PARP-1 activity or gene expression had the opposite effect on these cells. PARP-1-deficient cells also had reduced a-SMA gene expression. PARP-1 can affect the binding of smad3 to a-SMA promoter by inhibiting DNA methylation of a-SMA gene. PARP activity in lung fibroblasts isolated from idiopathic pulmonary fibrosis patients was significantly higher than that in cells isolated from control subjects. PARP-1-deficient mice exhibited reduced pulmonary fibrosis in response to bleomycin-induced lung injury."